Contribution of High-Mobility Group Box-1 to the Development of Ventilator-induced Lung Injury
نویسندگان
چکیده
منابع مشابه
Contribution of high-mobility group box-1 to the development of ventilator-induced lung injury.
RATIONALE Proinflammatory cytokines play an important role in ventilator-induced lung injury (VILI). High-mobility group box-1 (HMGB1) is a macrophage-derived proinflammatory cytokine that can cause lung injury. OBJECTIVES This study tested the hypothesis that HMGB1 is released in intact lungs ventilated with large Vt. A second objective was to identify the source of HMGB1. A third objective ...
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متن کاملLung development and susceptibility to ventilator-induced lung injury.
RATIONALE Ventilator-induced lung injury has been predominantly studied in adults. OBJECTIVES To explore the effects of age and lung development on susceptibility to such injury. METHODS Ex vivo isolated nonperfused rat lungs (infant, juvenile, and adult) were mechanically ventilated where VT was based on milliliters per kilogram of body weight or as a percentage of the measured total lung ...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2006
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.200605-699oc